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apalutamide will decrease the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medications that are CYP3A4 substrates may lead to reduce exposure to these remedies.Modafinil might be habit-forming. By no means share mo